Kudzu Treatment for Alcohol Abuse Full Text View

Older studies show St. John’s wort may help to reduce alcohol intake and relieve withdrawal symptoms in animals. These heavy drinkers (who weren’t seeking treatment) also spent fewer days binge drinking and actually abstained from drinking alcohol for longer periods of time while supplementing with kudzu (x). Genistein possesses high histone modifying activity compared with other isoflavones, such as diadzein and biochanin A [27]. Studies mostly supported a genistein-mediated increase in acetylation marks and selective demethylation or hypermethylation effects.

  • Scientists need to do more research on the effects of kudzu root in humans to investigate these effects in the liver.
  • One limitation of this study is the lack of a dose-response assessment.
  • Isoflavones are considered to be phytoestrogens and are distributed mostly in legume-based dietary supplements.
  • This defect drives individuals to engage in activities of behavioral excess, which will increase brain dopamine function, for which we created the term Reward Deficiency Syndrome (RDS) [59] to categorize such biological influences on behavior.
  • The information we provide while responding to comments is not intended to provide and does not constitute medical, legal, or other professional advice.
  • They then either took 500 mg kudzu plant capsules three times a day or a placebo for a week and then returned to the lab.
  • All fruits and plants contain a plethora of different phytonutrients.

I did not know at the time that people also use kudzu to treat alcohol withdrawal symptoms; nor did I care, because I did not intend to quit at the time. It may seem counterintuitive that kudzu plant can work both as a hangover cure and to curb the desire to drink, but the same elements that help ease the physical consequences may push the body to feel alcohol’s effects sooner. They propose that the suppression of alcohol reinforcement produced by kudzu plant compounds is mediated centrally in the brain reward pathway. Lukas and Lee applied for, and were granted, a patent for kudzu extract to treat alcohol abuse and dependence.

Tamoxifen (Nolvadex) interacts with KUDZU

The study found the treatment with the kudzu extract resulted in a significant reduction in the number of beers consumed. Kudzu treatment also resulted in the number of sips and length of time for consuming each beer, as well as a decrease in the volume of each sip. Individuals treated with kudzu extract drank less beer, and they drank more slowly. There were no reported side effects from treatment with the kudzu extract. The herb called the kudzu is a high climbing, coarse textured twining and trailing type of perennial vine found in parts of Asia and naturalized elsewhere [1].

What herbs are used to treat alcoholism?

Herbal supplements like Ashwagandha, kudzu, milk thistle, and St. John's wort may reduce alcohol withdrawal symptoms and prevent cravings. Lifestyle changes, better nutrition, exercise, meditation, mindfulness, and relaxing hobbies can also help you feel better while living alcohol-free.

Overconsumption of alcohol has significant negative effects on an individual’s health and contributes to an enormous economic impact on society as a whole. Pharmacotherapies to curb excessive drinking are important for treating alcohol https://ecosoberhouse.com/article/here-is-how-alcohol-affects-your-skin/ use disorders. «Investigators may not be willing to take the extra steps that might be necessary to conduct such a study,» such as extracting the critical isoflavones from kudzu and partnering with clinical researchers, Overstreet says.

A standardized kudzu extract (NPI- reduces alcohol consumption in nontreatment-seeking male heavy drinkers

Puerarin suppressed the addictionmediated abnormalities but did not affect the inflammation-related abnormalities. However, Lukas et al. [10] from McLean Hospital designed a study to test the efficacy of a kudzu extract in a clinical population. Specifically, male and female “heavy” alcohol kudzu extract for alcoholism drinkers were treated with either placebo or a kudzu extract for 7 days and then given an opportunity to drink their preferred brand of beer while in a naturalistic environment. They found that Kudzu treatment resulted in significant reduction in the number of beers consumed.

kudzu extract for alcoholism

Although daidzin and puerarin are isomeric and both found in kudzu root, they can be easily distinguished by LC-MS/MS [38]. Neutral losses of 162 and 120 da are characteristics of O- and C-glucosides of daizein, respectively in their MS/MS fragmentations. Kudzu is one of the earliest medicinal plants used in traditional Chinese medicine.