Life expectancy with fatty liver disease: What to know

By 2030, nonalcoholic steatohepatitis is predicted to become the leading indication for liver transplantation in U.S. adults, surpassing hepatitis C. NAFLD is a condition in which a person has a buildup of excess fat in their liver due to causes unrelated to alcohol. Research indicates that people with NAFLD may have a lower life expectancy than people who do not have NAFLD. A 2022 study, which examined the risk of cardiovascular disease and life expectancy in NAFLD, found that people with NAFLD may have a lower life expectancy of about 2.8 years compared with people without NAFLD. A weight loss of approximately 5- 10% of your body mass will certainly improve the condition in patients suffering from NAFLD.

how long can you live with non alcoholic fatty liver disease

To remove any cellular debris, the collected medium was filtered through a 0.22 μm filter (16532-K, Sartorius, Göttingen, Germany). For people with cirrhosis, there is a close link between life expectancy and the number of symptoms and complications they experience. Of people who develop cirrhosis, 20–60% also develop malnutrition, additional complications, longer hospital stays, and a reduced life expectancy. Despite its severity, the condition is not rare, as millions of people in the United States are living with cirrhosis. This number could be even higher, as many people do not receive a diagnosis until they develop advanced symptoms.

Life Expectancy With Cirrhosis of the Liver: What to Expect

NAFLD, but also the components of metabolic syndrome, are chronic diseases. They sometimes cause other chronic diseases or co-exist with other diseases. All these diseases are frequently treated by several different (specialised) physicians and other healthcare providers. Nevertheless, they are not strictly separated but frequently interact.

how long can you live with non alcoholic fatty liver disease

And, only a minority of people with NASH will progress to develop cirrhosis. It is not clear why some people with simple fatty liver alcoholic liver disease progress to the more severe forms of NAFLD, and most do not. Cirrhosis of the liver is the last stage of alcoholic liver disease.

When to see a doctor

Liver cell damage and inflammation constitute what is called the “activity” of the disease. This is the active process that drives the development of scar tissue and the worsening of the disease towards cirrhosis and liver failure (end-stage liver disease). Several scoring systems have been developed over time to indicate the level of disease activity. As already described, you as a patient have an active role in your treatment.

This positive link between the improvements in liver biopsy and your long-term outcome has, however, not been scientifically proven. Therefore, the phase III trials currently go on beyond the first treatment period and first control biopsy. The long-term phase of these studies is meant to see whether patients in the end really do better and develop less disease events. It will only be based on these end-of-study results on true clinical events that final approval can be granted.

Nonalcoholic Steatohepatitis (NASH)

The first enrollment of patients took place from 9 March 2005 to 6 September 2011. The mean duration of follow-up was 64.5 ± 24.5 months, with a median follow-up period of 63.0 (ranging from 13.8–127.4) months. All cells were cultured in a humidified incubator at 37 °C with 5% CO2. Cell lines were obtained from ATCC (Virginia, USA) with the exception of MIHA, which was purchased from Yaji Biotechnology Co. (Shanghai, China).

High levels of liver enzymes could also suggest other liver diseases. Your doctor will need to rule out other conditions before diagnosing NAFLD. Healthcare providers recommend losing at least 3% to 5% of your body weight to begin to see results in your liver. (Current research suggests that even 1% weight loss may improve outcomes.) They also recommend that you aim to lose no more than 1 to 2 pounds per week.